3-chloro-6-methyl-dibenzo[c,f][1,2]thiazepin

• Post Date:

  Dec 07,2018

• Expiry Date:

  Dec 07,2019

• Detailed Description:

  Cas No. :26638-53-9 3-Chloro-6-methyl-dibenzo [c,f][1,2]thiazepin-11(6H)-one 5,5-dioxide,a key intermediate of Tianeptine,was synthesized from 4-chloro-2-sulfonylchloride methyl benzoate via condensation,methylation,hydrogenolysis and cyclization in an overal yield of 55.9%.The influences of acid-capturer pyridine dosage on condensation and sodium hydride dosage on hydrogenolysis were optimized as follows:n(4-chloro-2-sulfonylchloride methyl benzoate):n(pyridine)=1:1.86,n(4-chloro-2-(N-methyl-N-phenylsulphonamide)methyl benzoate):n(sodium hydride)= 1:3.The optimal temperature for cyclization reaction was obtained to be 100～110℃.IR,1H NMR and MS were used for structure identification.

• CAS Registry Number:

  26638-53-9

• Synonyms:

  ;3-Chloro-6-methyl-S,S-dioxyde-dibenzo[c,f]thiazepin-11(6H)-one;3-chloro-6,11-dihydro-5,5,11-trioxo-6-methyldibenzo[c,f][1,2]thiazepine;

• Molecular Formula:

  C₁₄H₁₀ClNO₃S

• Molecular Weight:

  307.7521

• Molecular Structure:

  

• Company:

  Jinan Chenghishaungda Chemical Co.,LTD     [ China ]        

• Contact:

  Allen

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  15689693073

• Fax:

  0531-58897032

• Email:

  3118607598@qq.com